15th of June 2022: Abstract submission for the International Magnetic Resonance Spectroscopy Workshop “MRS 2022: Overcoming the Barriers to Clinical Use”

Community & Education
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Dear MR Spectroscopists, Dear colleagues, Dear friends,

:alarm_clock: :mega: Time is ticking
The deadline for the abstract submission for the International Magnetic Resonance Spectroscopy Workshop “MRS 2022: Overcoming the Barriers to Clinical Use” is *15th of June 2022.

We look forward in receiving your contributions, work in progress, independently of their past submissions. Homepage - MRS Workshop 2022 (cibm.ch)

20 abstracts will be selected for oral presentations and the rest for poster presentations. Travel awards will be offered. We are in discussions for organizing a Special Issue.

We also had different questions for the abstract format: Your Abstract, Your Way :blush:, just fit all the abstract in 1 page (Letter or A4)

  • 1 page A4/Letter in PDF format with minimum font size of 10pt including title, co-authors, affiliations, figures and references. Nice figures are always welcomed to highlight your amazing data :slight_smile:

  • Please send your abstract by email to cristina.cudalbu@epfl.ch and jwijnen@umcutrecht.nl with “MRS workshop 2022 abstract submission” in the title

For PhD students we have several “Meet the experts” sessions – please contact dunja.simicic@epfl.ch if you wish to help with the organization, have new ideas and wishes.

Hotels have been preserved at lower rates, but some will be released as end of May, Don’t miss out and re serve today – all details are provided on our web page, the reservation code works only by email ! with cancelation policy .

Venue & Travel info - MRS Workshop 2022 (cibm.ch)

The workshop is endorsed by the ISMRM.

We look forward to welcoming you on-line or in person on August 22-24 at the EPFL campus in Lausanne. Don’t miss out and register today!

With our best wishes,

Your Scientific Organizing Committee

Cristina Cudalbu, Ph.D., (chair), CIBM MRI EPFL, Lausanne, Switzerland

Jannie P. Wijnen, Ph.D., (co-chair), UMCU, Utrecht, The Netherlands

Wolfgang Bogner, Ph.D., Medical University Vienna, Austria

Christoph Juchem, Ph.D., Columbia University, New York, USA

Dinesh K. Deelchand, Ph.D., CMRR, University of Minnesota, USA

Dunja Simicic, M.Sc., CIBM MRI EPFL, Lausanne, Switzerland

George Bouzalis, Ygeia Ptolemaidas diagnostic center, MR Department, Kozani, Greece

Alexander P. Lin, Ph.D., Brigham and Women’s Hospital, Harvard Medical School, Boston, USA

Roland Kreis, Ph.D., University of Bern, Bern, Switzerland

Dimitri Van De Ville, Ph.D., CIBM MRI EPFL, Lausanne, Switzerland

REGISTER_MRSworkshop2022_02
REGISTER_MRSworkshop2022_021920×1080 227 KB

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:watch::loudspeaker:Time is ticking - 2 days left to submit your abstract to the MRS 2022 Workshop - deadline 15th of June 2022 and afterwards to the Special Issue in NMR Biomed

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Dear All,

Following the MRS workshop some participants were interested in the # References for ‘Neurochemical Profile’: talk by S R Williams at MRS Workshop 2022

Sensitivity, Resolution, Overlap

Davies, S.E.C., Newcombe, J., Williams, S.R., McDonald, W.I. and Clark, J.B. (1995), High Resolution Proton NMR Spectroscopy of Multiple Sclerosis Lesions. Journal of Neurochemistry, 64: 742-748.

  • 7T Human Brain Spectrum in vivo
    • Godlewska et al Neurochemical abnormalities in chronic fatigue syndrome: Psychopharmacology (Berl). 2022 239:163-171
  • Biochemistry of MRS metabolites
    • Rae,CD Neurochem Res (2014) 39:1–36 A guide to the Metabolic Pathways and Function of Metabolites
  • GABA methods
    • Mullins PG, McGonigle DJ, O’Gorman RL, Puts NA, Vidyasagar R, Evans CJ; Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA. Neuroimage. 2014 Feb 1;86:43-52
  • Measuring Aspartate by MRS
    • Non-edited, metabolite cycling, 9.4T, sLASER TE 24ms

Giapitzakis et al. (2018), Magn. Reson. Med, 79: 1841-1850.

Hermes editing of aspartyl H, 3T, large voxel 45ml, TE 150ms

Chan et al. Neuroimage. 2017 155:587-593

Measuring Glycine – minimize mIno

Long TE/multiple refocusing

Measurement of glycine in human brain by triple refocusing 1H-MRS in vivo at 3.0T. Choi C, Bhardwaj PP, Seres P, Kalra S, Tibbo PG, Coupland NJ.Magn Reson Med. 2008 59:59-64.

high field with short TE to minimize mIno

In vivo measurement of glycine with short echo-time 1H MRS in human brain at 7 T. Gambarota G, Mekle R, Xin L, Hergt M, van der Zwaag W, Krueger G, Gruetter R. In vivo measurement of glycine with short echo-time 1H MRS in human brain at 7 T. MAGMA. 2009 22:1-4

  • Glucose
    • Can be used to report brain glucose levels
      • Pfeuffer J, Tka´c I, Gruetter R (2000) Extracellular-intracellular distribution of glucose and lactate in the rat brain assessed noninvasively by diffusion-weighted 1H nuclear magnetic resonance spectroscopy in vivo. J Cereb Blood Flow Metab 20:736–746
      • de Graaf RA, Pan JW, Telang F, Lee JH, Brown P, Novotny EJ, Hetherington HP, Rothman D (2001) Differentiation of glucose transport in human brain gray and white matter. J Cereb Blood Flow Metab 21:483–492

NAA

  • NAA is expressed in Neurons, but also some Glial cells
    • Urenjak et al. J.Neurosci. 13, 981 1992
  • NAA levels can recover following stroke, MS and mitochondrial disorders
    • Continuing ischemic damage after acute middle cerebral artery infarction in humans demonstrated by short-echo proton spectroscopy. Saunders et al 1996, Stroke 26, 1007-1013
    • Reversible Loss of N-Acetyl-Aspartate in Rats Subjected to Long-Term Focal Cerebral Ischemia de Mougeot et al JCBF Met 23:482 (2003)
  • NAA presence in oligodendrocyte precursors and oligodendrocytes supports role in myelination

Bhakoo KK, Pearce D. In vitro expression of N-acetyl aspartate by oligodendrocytes: implications for proton magnetic resonance spectroscopy signal in vivo. J Neurochem 2000;74(1):254-62.

Consistent with role as acetyl transporter for lipid synthesis

Patel TB, Clarke JB. Lipogenesis in the brain of suckling rats. Biochem.J. 1980;188:163-168.

Reporter of neuronal mitochondrial function

Bates et al. Neuroreport, 1996 7:1341-1447: Mitochondrial NAA production, ATP production and oxygen consumption were all significantly decreased in the presence of mito inhibitors

Myo-Inositol

  • myo -Inositol is expressed in glia
    • Brand A, Richter-Landsberg C, Leibfritz D… Dev Neurosci 1993;15(3-5):289-98
  • myo -Inositol is also found in other cells

Proton nuclear magnetic resonance spectroscopy of primary cells derived from nervous tissue. Bhakoo KK, Williams IT, Williams SR, Gadian DG, Noble MD. J.Neurochem. 1996;66:1254-1263.

  • Myo-inositol and neurodegeneration
    • Miller et al. S, Ross BD. Alzheimer disease: depiction of increased cerebral myo-inositol with proton MR spectroscopy. Radiology. 1993 187:433-7.
  • Choline-containing compounds and Phosphoethanolamine
    • GPC>PC>Cho in extracts of human brain: ~ 1:0.3:0.2
      • Ala-Korpela et al J Magn Reson (1996) B113: 184-189
    • Choline compounds as markers of proliferation

Many studies have shown that Cho-compounds increase in brain tumours

Usenius et al J.Neurochem 1994 63:1538

cell-culture suggests this is driven by an increase in PC

Florian et al. NMR Biomed. 1995 8:253-64.

Glutathione Measurements

Signal can be revealed with spectral editing

* Sanaei Nezhad, F., Anton, A.[, Parkes, L. M.](https://www.research.manchester.ac.uk/portal/laura.parkes.html)[, Deakin, B.](https://www.research.manchester.ac.uk/portal/bill.deakin.html)[, & Williams, S. R.](https://www.research.manchester.ac.uk/portal/steve.williams.html) (2017). [Quantification of Glutathione in the Human Brain by MR Spectroscopy at 3 Tesla: Comparison of PRESS and MEGAPRESS](https://www.research.manchester.ac.uk/portal/en/publications/quantification-of-glutathione-in-the-human-brain-by-mr-spectroscopy-at-3-tesla-comparison-of-press-and-megapress(850daaae-7ea6-44ce-9504-40e8cae31dc9).html). *Magnetic Resonance in Medicine*, *78*(4), 1257-1266
  • Ascorbate – an anti-oxidant

9.4T longitudinal rat hepatic encephalopathy model in vivo

Braissant et al. J Hepatol. 2019;71:505-515

Taurine

Low concn in mature human brain (~1.5 mMol/kg)

Pouwels et al. Pediat Res 1999 46:474

Davies et al J Neurochem 1995 64: 742-748

Significant changes during development (negative correlation with NAA)

'H NMR Study of Cerebral Development in the Rat. Bates et al. NMR Biomed 1989 2:225

Elevated concn in the eye and retina

Florian et al. Neurochem Res 1996 21:1065-1070

Taurine and Astrocytes: A homeostatic and Neuroprotective Relationship

Ramirez-Guerrero et al Front Mol Neurosci 2022 15:937789

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Interested in watching the presentations from the MRS workshop 2022 ? Huge thanks to all the incredible speakers and organizers.
Agenda - MRS Workshop 2022 (cibm.ch)

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Hi Cristina @cudalbu , unfortunately it seems that the agenda webpage is no more (and though on the wayback machine, the key content wasn’t archived). When you have the time would you be so kind as to share the link to the YouTube channel here?

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Not to worry. I found them in the page source on the archive!

Day 1 recording
Day 2 recording
Day 3 recording

All the videos are timestamped:

Day 1
00:00 Intro
21:55 Basics of MRS: SVS and MRSI
46:00 The neurochemical profile
1:15:20 Spectral editing
1:43:10 MRSHub - What's next
2:10:30 Artifacts and Correction in MRS and MRSI
2:37:16 Quality control & preprocessing
3:06:00 Fast prospective motion correction for spectroscopic acquisitions
3:18:20 Deep Learning Pipeline for Quality Filtering of MRSI Spectra
3:36:13 Effect of circadian rhythm on brain NAD: a magnetic resonance spectroscopy study at 7T
3:53:00 Accelerated MRSI and reconstruction
4:21:26 Accelerated MRSI: conventional approaches
4:53:45 Outlier Rejection for Fetal and Neonatal Brain MRS
5:06:10 Towards simultaneous concentration and T2 mapping of brain metabolites by multi-echo spectroscopic imaging
5:18:50 MP-PCA and LR-TGV denoising in 1H-FID-MRSI data at 14.1T: application and validation
5:31:50 Downfield proton MRSI in the human brain with extended spatial coverage

Day 2
00:20 Metabolite basis set simulations
28:15 Parametric fitting
1:00:38 Quantification: references, T1, T2 and macromolecules
1:29:00 Investigating Glutamate T2 relaxation time
1:42:40 Preclinical MRS
2:10:30 Translational work bench-bedside
2:53:20  Methods for non-brain translational and clinical MRS
3:22:10 α-ATP suppression in 31P MR spectroscopy by homonuclear BIRD editing: An approach to quantify NADH and NAD+ at 3T in vivo in skeletal muscle
3:35:15 Association of insulin resistance with the accumulation of saturated IMCL, compared with other fat stores
3:46:10 Validation, reproducibility/repeatability in MRS
4:12:42 Vendor harmonization in MRS
4:36:10 Denoising for MRS and MRSI
5:03:50 Machine learning for MRS/MRSI

Day 3
00:40 Brain MRS in psychiatry
32:05 Brain MRS in cancer
1:03:08 MRS in pediatrics
1:34:15 MRS application in liver and muscle
2:01:30 Accurate prediction of IDH-mutation status of gliomas using SLOW- editing MRSI at 7 Tesla MR
2:18:21 Probing diffusion of water and metabolites to assess white matter microstructure in Duchenne muscular dystrophy
2:30:42 Deuterium MRSI
3:03:30 Hyperpolarized 13C: where are we in the clinic ?
3:32:20 Retrospective under-sampled 3D Deuterium Metabolic Imaging (DMI) of the Human Liver with Low-rank and Subspace Modeling at 7T
3:45:25 Comparing cerebral metabolism of hyperpolarized 13C-glucose and thermally polarized deuterated glucose under different anesthetic conditions
4:06:05 Non-invasive 3D mapping of downstream brain glucose metabolism using 1H MRSI with deuterium labeling at 3T
4:19:06 DMI using different doses of [6,6′-2H2]-glucose for real-time in vivo liver glucose mapping at 7T
4:33:56 Anesthetic-related neuroenergetic changes measured with 1H- and 31P-MRS in mouse at 7 Tesla
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