Any idea what went wrong with the fitting of this spectrum from the medial prefrontal cortex? The NAA peaks are visible in the raw spectra, and have a reasonable quantification that aligns with other values from the data set, but has been nearly completely eliminated in the “aligned and averaged” and “LC model” windows. Is the spectral quality to blame? Would I have to exclude this as a failed scan? Or is this more consistent with a flaw in the fitting algorithm or something else specific to HERCULES or Osprey?
Please find the (low quality pdf) file with our results attached.
Option 3 (see below) gave the best results. I guess we should now implement these lines also for analysis of the other data which did not show the problem to be consistent?