Clarification on units for tissue-corrected water-scaled metabolites in Osprey (LCModel fitting)

Analysis / Modeling
1

Hi everyone,

I am relatively new to MRS data processing and am using Osprey with LCModel fitting for short-TE unedited data. Osprey provides tissue-corrected water-scaled metabolite estimates, but I would like to confirm how to interpret the units of these values when LCModel is used for model fitting rather than Osprey’s own fitting.

My questions:

  1. When using LCModel via Osprey, do the tissue-corrected water-scaled metabolite estimates correspond to a quantitative concentration unit (e.g., molal, mmol/kg), or should they be treated as institutional units?

  2. Do I need to modify anything in the LCModel control file to ensure correct quantitative scaling, or does Osprey handle this internally?

Any clarification on unit conventions when using LCModel within Osprey, and whether LCModel control-file settings affect the final tissue-corrected values, would be greatly appreciated. If there is a recommended wording for describing this quantification approach in a Methods section, I would also be grateful.

Thanks in advance!