GM vs WM basis set

Analysis / Modeling Basis Sets
1

Hello!

Sorry for the (possibly) naive question. We are setting up our MRS analysis for an upcoming study. Our MR tech gave us two basis sets, appended with _GM and _WM. I am using the LCModel fitting option in Osprey, and using Osprey to perform voxel coregistration and segmentation for tissue corrected values. Do you have a recommendation on which to use? Does the use of coreg and segmentation negate the differences in these basis sets? I have never seen the use two separate basis sets before, so any insight would be greatly appreciated!

Best,
Jessica

2

The only reason I can possibly think of is that the two basis sets have specific measured macromolecular background basis functions for GM and WM.

I’d recommend you do a fit with both and paste some screenshots so we can appreciate if there’s any meaningful difference. (Ideally also ask your tech about the provenance of these basis sets)