LCModel baseline

Hello,everyone! I met some question about data analysis. When using LCModel to analyze data with the basis generated by MRSCloud, I’ve noticed that the baseline on the left side is elevated. I’m wondering if this is due to the presence of water in the basis? I’m sincerely curious about the reasons behind this and how it might affect the results.

Thanks in advance!


Yes, that’s possible - I would exclude H2O from the basis set. You can do that by editing the control file, adding a line chomit(x) = 'H2O', where x is a running index for all the omitted metabolites. See section 9.8 in the LCModel manual.

Thanks for your advice! The baseline is quite flat after excluding H2O.