The discussion regarding whether Gannet can fit Glu or Glx

MRS Software Gannet
1

hello,
I would like to inquire whether, solely by executing the MEGA-PRESS sequence scan, the post-processing function of the Gannet software package can obtain the glutamate signal at 2.35 ppm. Does Gannet only have the ability to fit the Glx signal at the 3.75 ppm position?

2

Hi @wyw12345,

The latest version of Gannet does (automatically) fit the 2.35 Glu signal in the SUM spectrum of spectral-edited data. However, this fitting has not been thoroughly tested so I can’t speak to its reliability. Its reliability will also heavily depend on the TE of the acquisition.

Mark

3

Hello Mark
Thank you for your response. These are the parameters used by our MRS: TR: 2000 ms; TE: 68 ms; Spectral bandwidth: 5000 Hz, Points: 4096; 1.9 ppm (ON) and 7.5 ppm (OFF); Edit ON acquisitions = 128, Edit OFF acquisition = 128.However, I found that my Gannet 3.3.2 could only fit the Glx signal at 3.75 ppm. Is this a limitation of this MEGA-PRESS method, or could I separately fit the 2.35 ppm Glu signal in the Edit off spectrum?

4

Please use the latest version (v3.5.1) to fit the 2.35 Glu peak.

5

I understand. Thank you for your reply.