I read some 1H single voxel MRS papers and the majority of them show metabolites quantification for the range of 0.2 to 4.5 ppm.
Is there any reason to don’t quantify metabolites whose ppm are at the left of the H2O peak? Don’t you think that this way leads to an underestimation of some important metabolites since we don’t quantify all of their peaks? Like :Cr (missed pic at 6.64 ppm), pCr (missed pics at 6.58 and 7.29ppm), Ins (missed pic at 6.39 ppm), Glc (missed pic at 5.21 ppm)…
Also, I made a comparison between a “classical” ppm range (0.2-4.2 ppm) and an “extended” ppm range (0.2 to 8.2 ppm) and I found a significant difference between the two quantification ways of the metabolites ratios (/tCr) . How can someone choose the correct way/ratios in this situation?
Please feel free to comment and discuss.