I am conducting 7T short TE STEAM experiments to detect GABA. Following the recommendations, I have decided to use experimentally measured MM during the fitting. As I am unfamiliar with experimentally measuring MM, I initially want to use publicly available MM basis or those permitted by the authors.
Lately, I have been troubled by a question: even if I recruit volunteers in the same age range and place voxels in the same brain region as the authors did, considering that these two groups of volunteers are completely different individuals, to what extent would experimentally measured MM basis introduce inaccuracies in fitting low-concentration metabolites such as GABA?
May I ask if anyone has considered this question or could share relevant papers with me? I would greatly appreciate it.