I am writing regarding the post of Prof Paul Mullins on his blog.
I understand the need of taking into account tissue composition within the voxel. Indeed, LCModel has such an option of corrections both water concentration (wconc) and T2 relaxation (atth2o). Comparing the equations provided in LCModel’s manual with eg. J. Near et al. 2020, one can spot that S. Provencher does not consider tissue specific relaxation rates. I’ve got 2 questions then:
- Does the correction for the tissue adjusted water concentration combined with the updated t2 water attenuation factor is the state-of-the-art (LCModel)? Or should the results be taken out to be corrected for all the possible relaxation/concentration terms?
- Is it possible to include all the tissue specific corrections within LCModel pipeline? It seems to be more convenient to first run a segmentation and then quantify the spectra accordingly to the derived parameters.
Looking forward to Your comments and clarification